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Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats

โœ Scribed by Whei-Mei Wu; Fenglei Huang; Yangsuk Lee; Peter Buchwald; Dr. Nicholas Bodor

Book ID
111770798
Publisher
Pharmaceutical Press
Year
2008
Tongue
English
Weight
257 KB
Volume
60
Category
Article
ISSN
2042-7158

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In a recent paper in this Journal, Hochhaus et al.? discussed the pharmacokinetics and distribution of the soft glucocorticoid 1 in rats and dogs. The basis for the interest in an ester of a steroidal 20-carboxylic acid as a soft drug was that the anticipated rapid metabolism of 1 to the correspondi