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Soft Drugs 19. Pharmacokinetics, Metabolism and Excretion of a Novel Soft Corticosteroid, Loteprednol Etabonate, in Rats

✍ Scribed by Nicholas Bodor; Whei-Mei Wu; Teruo Murakami; Steven Engel


Book ID
110346769
Publisher
Springer US
Year
1995
Tongue
English
Weight
843 KB
Volume
12
Category
Article
ISSN
0724-8741

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Comments concerning “pharmacokinetic cha
✍ Kenneth B. Sloan; John H. Perrin 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

In a recent paper in this Journal, Hochhaus et al.? discussed the pharmacokinetics and distribution of the soft glucocorticoid 1 in rats and dogs. The basis for the interest in an ester of a steroidal 20-carboxylic acid as a soft drug was that the anticipated rapid metabolism of 1 to the correspondi