Response to the commentary on “pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs”

Comments concerning “pharmacokinetic cha

Comments concerning “pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs”

✍ Kenneth B. Sloan; John H. Perrin 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

In a recent paper in this Journal, Hochhaus et al.? discussed the pharmacokinetics and distribution of the soft glucocorticoid 1 in rats and dogs. The basis for the interest in an ester of a steroidal 20-carboxylic acid as a soft drug was that the anticipated rapid metabolism of 1 to the correspondi