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Comments concerning “pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs”

✍ Scribed by Kenneth B. Sloan; John H. Perrin

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 149 KB
Volume: 83
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600830729

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✦ Synopsis

In a recent paper in this Journal, Hochhaus et al.? discussed the pharmacokinetics and distribution of the soft glucocorticoid 1 in rats and dogs. The basis for the interest in an ester of a steroidal 20-carboxylic acid as a soft drug was that the anticipated rapid metabolism of 1 to the corresponding inactive steroidal 4 5

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