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Metabolism, Distribution, and Transdermal Permeation of a Soft Corticosteroid, Loteprednol Etabonate

โœ Scribed by Nicholas Bodor; Thorsteinn Loftsson; Whei-mei Wu

Book ID
110341809
Publisher
Springer US
Year
1992
Tongue
English
Weight
677 KB
Volume
09
Category
Article
ISSN
0724-8741

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In a recent paper in this Journal, Hochhaus et al.? discussed the pharmacokinetics and distribution of the soft glucocorticoid 1 in rats and dogs. The basis for the interest in an ester of a steroidal 20-carboxylic acid as a soft drug was that the anticipated rapid metabolism of 1 to the correspondi