𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetics of N′-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in laboratory animals

✍ Scribed by Adams, John D.; Lavoie, Edmond J.; O'Mara-Adams, Kathleen J.; Hoffmann, Dietrich; Carey, K.Dee; Marshall, Milton V.

Book ID
123578663
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
469 KB
Volume
28
Category
Article
ISSN
0304-3835

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of 4- (methylnitrosamino)-1- (
Synthesis of 4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone, 4- (carbethoxynitrosamino)-1- (3-pyridyl)-1-butanone, and N′ -nitrosonornicotine labelled with tritium in the pyridine ring
✍ James C. Wiley Jr.; David H. T. Chien; Nancy A. Nungesser; Dorothy Lin; Stephen 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 349 KB

The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c

High-performance liquid chromatographic
High-performance liquid chromatographic analysis of metabolites of the nicotine-derived nitrosamines, N′-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
✍ Steven G. Carmella; Stephen S. Hecht 📂 Article 📅 1985 🏛 Elsevier Science 🌐 English ⚖ 427 KB

An improved high-performance liquid chromatographic system was developed for separation of 11 metabolites of the nicotine-derived nitrosamines N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The new system employed a 5-microns octadecylsilane bonded column elute