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Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxy)pyridyl]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents

✍ Scribed by Desai, Dhimant; Kagan, Shashi S.; Amin, Shantu; Carmella, Steven G.; Hecht, Stephen S.

Book ID
125960948
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
778 KB
Volume
6
Category
Article
ISSN
0893-228X

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Synthesis of 4- (methylnitrosamino)-1- (
Synthesis of 4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone, 4- (carbethoxynitrosamino)-1- (3-pyridyl)-1-butanone, and Nβ€² -nitrosonornicotine labelled with tritium in the pyridine ring
✍ James C. Wiley Jr.; David H. T. Chien; Nancy A. Nungesser; Dorothy Lin; Stephen πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 349 KB

The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c