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Glucuronidation of 4-[(Hydroxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone, a Metabolically Activated Form of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, by Phenobarbital-Treated Rats

โœ Scribed by Murphy, Sharon E.; Spina, Deborah A.; Nunes, Maria G.; Pullo, Dominic A.


Book ID
127286411
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
925 KB
Volume
8
Category
Article
ISSN
0893-228X

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The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c