Metabolism of a glucuronide conjugate of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats
β Scribed by Sunday Ene-ojo Atawodi; Kathrin Michelsen; Elmar Richter
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 302 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0340-5761
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## Abstract Urinary metabolites of the tobaccoβspecific nitrosamine 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di
The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c
## Abstract ## BACKGROUND In the United States, Blacks who smoke cigarettes have a higher mean blood concentration of the nicotine metabolite cotinine than White smokers. It has not been determined whether there are racial differences in the exposure to the cigarette smoke carcinogen 4β(methylnitr