The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone modulation of cytokine release in U937 human macrophages
β Scribed by N. Rioux; A. Castonguay
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 132 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0340-7004
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## Abstract Urinary metabolites of the tobaccoβspecific nitrosamine 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di
The induction of micronuclei was studied in human diploid fibroblasts incubated in the presence of the tobacco-specific nitrosamine NNK. We used four fibroblast strains having a high capacity of O6-alkylguanine D N A alkyltransferase (13.0-23.3 pmol O6-methylguanine repaired per 8 Γ 10 6 cells) and
Sufficient evidence has demonstrated that cigarette smoking is causally associated with various types of human cancers. In the United States, about 90% of deaths from lung cancer among men and 79% of those among women are associated with smoking. Tobacco-specific nitrosamines are formed from nicotin