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Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits after intravenous administration

✍ Scribed by Mei-Ling Chen; Win L. Chiou

Book ID
112473550
Publisher
Springer
Year
1983
Tongue
English
Weight
826 KB
Volume
11
Category
Article
ISSN
1573-8744

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## Abstract The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (i.v.) injection of free MTX (treatment I), MTX‐loaded proliposomes (treatment II), and empty proliposomes mixed manually with free MTX (treatment III), 8 mg kg^βˆ’1^, to rats using an H