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Pharmacokinetics of 7-Hydroxy-methotrexate and Methotrexate in the Rat

✍ Scribed by Slørdal, L. ;Jaeger, R. ;Kjaeve, J. ;Aarbakke, J.

Book ID
114801058
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
390 KB
Volume
63
Category
Article
ISSN
0901-9928

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Pharmacokinetics of methotrexate and 7-h
Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits
✍ Heiko Iven; Helmut Brasch; Jörg Engster 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 551 KB

In rabbits the IV kinetics of MTX (1.33, 4 and 12 mg/kg) could be described by a linear three-compartment model with a terminal half-life between 2.4 and 3.6 h. During 8 h 50% of the dose was excreted into urine in unchanged form and 15% as the metabolite 7-OH-MTX. These fractions remained constant