In rabbits the IV kinetics of MTX (1.33, 4 and 12 mg/kg) could be described by a linear three-compartment model with a terminal half-life between 2.4 and 3.6 h. During 8 h 50% of the dose was excreted into urine in unchanged form and 15% as the metabolite 7-OH-MTX. These fractions remained constant
Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receivinglow-dose oral methotrexate
✍ Scribed by P. Sonneveld; F. W. Schultz; K. Nooter; K. Hählen
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 523 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0344-5704
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## Abstract A new high‐performance liquid chromatographic assay was used to determine methotrexate (MTX) and its main metabolite, 7‐hydroxymethotrexate (7‐OH‐MTX), in the plasma (n ‐ 17) and urine (n = 14) of children (age 3‐12 years) on maintenance therapy for acute lymphocytic leukemia (n = 14) o
A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtaine
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