Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia
β Scribed by Andrew D. J. Pearson; Steven Mills; Helen A. Amineddine; David R. Long; Alan W. Craft; Judith M. Chessells
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 515 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Intraindividual variation in 6-mercaptopurine (6-MP) kinetics has been little studied. It has now been examined in 18 children with acute lymphoblastic leukaemia (ALL). On 2 to 4 occasions in each patient drug concentrations in plasma and red cells were followed for 4 h after administration by means
We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (