Pharmacokinetics of low-dose methotrexate in children receiving maintenance therapy for acute lymphoblastic leukaemia
β Scribed by C. R. Pinkerton; S. G. Welshman; J. G. Kelly; R. G. Shanks; J. M. Bridges
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 414 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Intraindividual variation in 6-mercaptopurine (6-MP) kinetics has been little studied. It has now been examined in 18 children with acute lymphoblastic leukaemia (ALL). On 2 to 4 occasions in each patient drug concentrations in plasma and red cells were followed for 4 h after administration by means
The relationship between salivary methotrexate (MTX) concentration and severity of oral mucositis after administration of MTX was investigated in six children with acute lymphoblastic leukemia. They received two administrations of MTX at 500 mgm' with one third given bolusly and the remainder by 24-