𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia

✍ Scribed by Henrik Schrøder; Karsten Fogh


Publisher
Springer
Year
1988
Tongue
English
Weight
482 KB
Volume
21
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Oral mucositis and salivary methotrexate
✍ Ishii, Eiichi ;Yamada, Shin-Ichi ;Higuchi, Shun ;Honjo, Tetsu ;Igarashi, Hisaji 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 335 KB

The relationship between salivary methotrexate (MTX) concentration and severity of oral mucositis after administration of MTX was investigated in six children with acute lymphoblastic leukemia. They received two administrations of MTX at 500 mgm' with one third given bolusly and the remainder by 24-

Disposition of oral methotrexate in chil
✍ Koren, Gideon ;Solh, Hassan ;Klein, Julia ;Soldin, Stephen J. ;Greenberg, Mark 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 444 KB

We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (

Randomized comparison of moderate-dose m
✍ Lange, Beverly J.; Blatt, Julie; Sather, Harland N.; Meadows, Anna T. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 559 KB

Methotrexate (MTX) infusions of 500-1,000 mg/m2 over 24 hours may improve survival and prevent relapse in children with acute lymphoblastic leukemia (ALL). Childrens Cancer Group (CCG) Study 139 compared weekly oral methotrexate 20 mg/m2/ week (oral MTX) to MTX 500 mg/m2 infused over 24 hours (IV MT

Comparative study on the pharmacokinetic
✍ Borsi, Joseph D. ;Sagen, Erling ;Romslo, Inge ;Moe, Peter J. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 694 KB

## Abstract Concentrations of __7__‐hydroxy‐methotrexate (__7__‐OH‐MTX) were determined in serum samples obtained after 266 infusions of methotrexate administered to 58 children with acute lymphoblastic leukemia. The dose of methotrexate (MTX) was in the range of 0.5‐33.6 g/m^2^. Pharmacokinetic pa