The relationship between salivary methotrexate (MTX) concentration and severity of oral mucositis after administration of MTX was investigated in six children with acute lymphoblastic leukemia. They received two administrations of MTX at 500 mgm' with one third given bolusly and the remainder by 24-
Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia
✍ Scribed by Henrik Schrøder; Karsten Fogh
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 482 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0344-5704
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📜 SIMILAR VOLUMES
We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (
Methotrexate (MTX) infusions of 500-1,000 mg/m2 over 24 hours may improve survival and prevent relapse in children with acute lymphoblastic leukemia (ALL). Childrens Cancer Group (CCG) Study 139 compared weekly oral methotrexate 20 mg/m2/ week (oral MTX) to MTX 500 mg/m2 infused over 24 hours (IV MT
## Abstract Concentrations of __7__‐hydroxy‐methotrexate (__7__‐OH‐MTX) were determined in serum samples obtained after 266 infusions of methotrexate administered to 58 children with acute lymphoblastic leukemia. The dose of methotrexate (MTX) was in the range of 0.5‐33.6 g/m^2^. Pharmacokinetic pa