## Abstract ## Objective There is evidence supporting a therapeutic range for methotrexate polyglutamate (MTXGlu) concentrations in the treatment of rheumatoid arthritis (RA). Knowledge of the pharmacokinetics of MTXGlu~1โ5~ is required for optimal timing of blood sampling. The aim of this study w
โฆ LIBER โฆ
The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis.
โ Scribed by P Seideman; O Beck; S Eksborg; M Wennberg
- Book ID
- 117945460
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 791 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0306-5251
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The pharmacokinetics of methotrexate (MX) and 7-OH methotrexate (MXOH) was studied in 18 cancer patients treated with 6-hr intravenous (i.v.) infusion of 100 mglkg (A), 80 mglkg preceded by 20 mglkg i.v. loading dose (B), and 70 mg/kg preceded by 30 mglkg i.v. loading dose (C). Simultaneous analysis