Pharmacokinetics of methotrexate after intramuscular injection of methotrexate-polylysine conjugate in rabbits
β Scribed by Eun Jeong Yoon; Myung Gull Lee; Hee-Joo Lee; Man Ki Park; Chong-Kook Kim
- Book ID
- 112915225
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 277 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0253-6269
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π SIMILAR VOLUMES
The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (IV) and intramuscular (IM) injection of free MTX (treatment I), freshly prepared MTX-bearing positively charged liposomes (large unilamellar vesicles), PLUVs (treatment 11), and empty PLUVs mixed
In rabbits the IV kinetics of MTX (1.33, 4 and 12 mg/kg) could be described by a linear three-compartment model with a terminal half-life between 2.4 and 3.6 h. During 8 h 50% of the dose was excreted into urine in unchanged form and 15% as the metabolite 7-OH-MTX. These fractions remained constant
The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated following intra-articular injection of either MTX solution or controlled release MTX loaded microspheres in healthy rabbit joints. MTX solution or MTX loaded microspheres (size 30-100 mm) (10 mg MTX) was injected in