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Pharmacokinetics of methotrexate after intravenous and intramuscular injection of methotrexate-bearing neutral liposomes to rats

✍ Scribed by E. J. Bae; S. H. Lee; M. G. Lee; S. J. Hwang; Chong-K. Kim


Book ID
114738427
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
877 KB
Volume
18
Category
Article
ISSN
0269-4727

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## Abstract The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (i.v.) injection of free MTX (treatment I), MTX‐loaded proliposomes (treatment II), and empty proliposomes mixed manually with free MTX (treatment III), 8 mg kg^βˆ’1^, to rats using an H