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Pharmacokinetics and tissue distribution of methotrexate after intravenous injection of differently charged liposome-entrapped methotrexate to rats

✍ Scribed by Chong-Kook Kim; Mi-Kyung Lee; Jeong-Hee Han; Beom-Jin Lee

Book ID
113367904
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
688 KB
Volume
108
Category
Article
ISSN
0378-5173

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## Abstract The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (i.v.) injection of free MTX (treatment I), MTX‐loaded proliposomes (treatment II), and empty proliposomes mixed manually with free MTX (treatment III), 8 mg kg^βˆ’1^, to rats using an H