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Pharmacokinetics of methotrexate after intravenous and intramuscular injection of methotrexate-bearing positively charged liposomes to rats

✍ Scribed by Myoung M. Kim; Sun H. Lee; Myung G. Lee; Sung J. Hwang; Chong-K. Kim

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 803 KB
Volume: 16
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510160404

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✦ Synopsis

The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (IV) and intramuscular (IM) injection of free MTX (treatment I), freshly prepared MTX-bearing positively charged liposomes (large unilamellar vesicles), PLUVs (treatment 11), and empty PLUVs mixed manually with free MTX (treatment 'Addressee for correspondence.

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## Abstract The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (i.v.) injection of free MTX (treatment I), MTX‐loaded proliposomes (treatment II), and empty proliposomes mixed manually with free MTX (treatment III), 8 mg kg^−1^, to rats using an H