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Clearance studies of methotrexate and 7-hydroxy-methotrexate in rabbits after multiple-dose infusion

✍ Scribed by Mei-Ling Chen; Win L. Chiou

Book ID
112473551
Publisher
Springer
Year
1983
Tongue
English
Weight
723 KB
Volume
11
Category
Article
ISSN
1573-8744

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Pharmacokinetics of methotrexate and 7-h
Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits
✍ Heiko Iven; Helmut Brasch; JΓΆrg Engster πŸ“‚ Article πŸ“… 1985 πŸ› Springer 🌐 English βš– 551 KB

In rabbits the IV kinetics of MTX (1.33, 4 and 12 mg/kg) could be described by a linear three-compartment model with a terminal half-life between 2.4 and 3.6 h. During 8 h 50% of the dose was excreted into urine in unchanged form and 15% as the metabolite 7-OH-MTX. These fractions remained constant