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Cephalosporins increase the renal clearance of methotrexate and 7-hydroxymethotrexate in rabbits

โœ Scribed by Heiko Iven; Helmut Brasch


Publisher
Springer
Year
1990
Tongue
English
Weight
464 KB
Volume
26
Category
Article
ISSN
0344-5704

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โœ Heiko Iven; Helmut Brasch ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 583 KB

In anesthetized rabbits, continuous infusion of methotrexate (MTX; 30 micrograms kg-1 min-1) established steady-state plasma concentrations for MTX and the metabolite 7-hydroxymethotrexate (7-OH-MTX) within 40 min. Fifty percent of the infused dose was eliminated unchanged by the kidneys and the ren