The effects of antibiotics and uricosuri
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Heiko Iven; Helmut Brasch
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Article
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1988
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Springer
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English
โ 583 KB
In anesthetized rabbits, continuous infusion of methotrexate (MTX; 30 micrograms kg-1 min-1) established steady-state plasma concentrations for MTX and the metabolite 7-hydroxymethotrexate (7-OH-MTX) within 40 min. Fifty percent of the infused dose was eliminated unchanged by the kidneys and the ren