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Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition


Book ID
123299345
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
307 KB
Volume
11
Category
Article
ISSN
0197-4580

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The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant