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Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo

✍ Scribed by T. Thomsen; H. Kewitz


Book ID
118344414
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
455 KB
Volume
46
Category
Article
ISSN
0024-3205

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Stereoselectivity of cholinesterase inhi
✍ T. Thomsen; U. Bickel; J. P. Fischer; H. Kewitz πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 252 KB

The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant