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Galanthamine: pharmacokinetics, tissue distribution and cholinesterase inhibition in brain of mice

✍ Scribed by U. Bickel; T. Thomsen; J.P. Fischer; W. Weber; H. Kewitz

Book ID
118956362
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
841 KB
Volume
30
Category
Article
ISSN
0028-3908

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✍ T. Thomsen; U. Bickel; J. P. Fischer; H. Kewitz πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 252 KB

The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant