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Galanthamine pharmacokinetics and cholinesterase inhibition in mice

โœ Scribed by U. Bickel; T. Thomsen; J.P. Fischer; H. Kewitz

Book ID
115884133
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
119 KB
Volume
183
Category
Article
ISSN
0014-2999

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โœ T. Thomsen; U. Bickel; J. P. Fischer; H. Kewitz ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Springer ๐ŸŒ English โš– 252 KB

The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant