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Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition

โœ Scribed by Bickel, Ulrich; Thomsen, Torben; Weber, Willi; Fischer, Johannes P; Bachus, Rainer; Nitz, Manfred; Kewitz, Helmut

Book ID
109844951
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
828 KB
Volume
50
Category
Article
ISSN
0009-9236

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โœ T. Thomsen; U. Bickel; J. P. Fischer; H. Kewitz ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Springer ๐ŸŒ English โš– 252 KB

The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant