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Cholinesterase inhibition by galanthamine and lycoramine

โœ Scribed by R.L. Irwin; H.J. Smith III

Book ID
115767371
Publisher
Elsevier Science
Year
1960
Tongue
English
Weight
147 KB
Volume
3
Category
Article
ISSN
0006-2952

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The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant