Pharmacokinetics of coenzyme Q10
β Scribed by E. I. Kalenikova; E. A. Gorodetskaya; O. S. Medvedev
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 326 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0007-4888
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## Abstract A practical, highly stereoselective tenβstep synthesis of coenzyme Q~10~ (**1**) has been accomplished (overall yield __ca.__ 28%), starting from commercially available 2,3βdimethoxyβ5βmethylbenzoquinone (__Scheme__). The introduction of the first sideβchain isoprenyl group with (__E__)
Deuterium-labelled coenzyme Q 10 ([2-CD 3 -1 0 -CD 2 ]coenzyme Q 10 , coenzyme Q 10 -d 5 ) was synthesized by condensation of 2,3-dimethoxy-[5-CD 3 ]methyl-1, 4-hydroquinone with [1-CD 2 ]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination o
## Abstract Radioβlabelled coenzyme Q~10~, labelled at the 3β²βposition with ^14^C, was synthesized starting from natural solanesol and ethyl [3β^14^C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3β^14^C] acetoacetate. The specific radioactivity of the product was 44.8 ΞΌCi, 1.66 MBq/m