Human Coenzyme Q10Deficiency
β Scribed by Catarina M. Quinzii; Salvatore DiMauro; Michio Hirano
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 159 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-3190
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## Abstract A practical, highly stereoselective tenβstep synthesis of coenzyme Q~10~ (**1**) has been accomplished (overall yield __ca.__ 28%), starting from commercially available 2,3βdimethoxyβ5βmethylbenzoquinone (__Scheme__). The introduction of the first sideβchain isoprenyl group with (__E__)
Deuterium-labelled coenzyme Q 10 ([2-CD 3 -1 0 -CD 2 ]coenzyme Q 10 , coenzyme Q 10 -d 5 ) was synthesized by condensation of 2,3-dimethoxy-[5-CD 3 ]methyl-1, 4-hydroquinone with [1-CD 2 ]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination o