Anti-oxidative effect of coenzyme Q10
β Scribed by S. Sugiyama; M. Kitazawa; T. Ozawa; K. Suzuki; Y. Izawa
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 231 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1420-682X
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Little is known about the regulation of endogenous CoQ 10 levels in response to mitochondrial dysfunction or oxidative stress although exogenous CoQ 10 has been extensively used in humans. In this study, we first demonstrated that acute treatment of antimycin A, an inhibitor of mitochondrial complex
Deuterium-labelled coenzyme Q 10 ([2-CD 3 -1 0 -CD 2 ]coenzyme Q 10 , coenzyme Q 10 -d 5 ) was synthesized by condensation of 2,3-dimethoxy-[5-CD 3 ]methyl-1, 4-hydroquinone with [1-CD 2 ]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination o
## Abstract Radioβlabelled coenzyme Q~10~, labelled at the 3β²βposition with ^14^C, was synthesized starting from natural solanesol and ethyl [3β^14^C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3β^14^C] acetoacetate. The specific radioactivity of the product was 44.8 ΞΌCi, 1.66 MBq/m