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Pharmacokinetic studies of 9-nitrocamptothecin on intermittent and continuous schedules of administration in patients with solid tumors

โœ Scribed by Laura L. Jung; Ramesh K. Ramanathan; Merrill J. Egorin; Ruzhi Jin; Chandra P. Belani; Douglas M. Potter; Sandra Strychor; Donald L. Trump; Christine Walko; Marwan Fakih; William C. Zamboni


Publisher
Springer
Year
2004
Tongue
English
Weight
263 KB
Volume
54
Category
Article
ISSN
0344-5704

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A Phase I study of 9-nitrocamptothecin g
โœ M. Dror Michaelson; David P. Ryan; Charles S. Fuchs; Jeffrey G. Supko; Rocio Gar ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 83 KB ๐Ÿ‘ 1 views

## Abstract ## BACKGROUND 9โ€Nitrocamptothecin (9โ€NC) is an orally available camptothecin analog with antineoplastic activity that results from the inhibition of DNA topoisomerase I. Previous studies have suggested that it has significant clinical efficacy. The primary toxicities of 9โ€NC include ga