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Pharmacokinetics and toxicity of 120-hour continuous-infusion hydroxyurea in patients with advanced solid tumors

✍ Scribed by E. M. Newman; Mary Carroll; Steven A. Akman; Warren Chow; P. Coluzzi; Victor Hamasaki; Lucille A. Leong; Kim A. Margolin; Robert J. Morgan; James W. Raschko; Stephen Shibata; George Somlo; Merry Tetef; Y. Yen; Chul W. Ahn; James H. Doroshow


Publisher
Springer
Year
1996
Tongue
English
Weight
118 KB
Volume
39
Category
Article
ISSN
0344-5704

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## Abstract To determine the maximum tolerated dose of 5‐fluorouracil administered as a 120‐hour continuous intravenous infusion to pediatric patients, we performed a phase I study using a starting dosage of 900 mg/m^2^/day. The maximum tolerated dosage (MTD) was 1,100 mg/m^2^/day. At this dosage l

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ICRF-187 was given to 62 evaluable patients with advanced solid tumors in a Phase I clinical trial. Weekly infusions were given in dosages ranging from 0.85 g/m2 to 7.42 g/m2 for a total of four weeks with a two week rest period between courses. Dose-limiting hematological toxicity was seen in heavi