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Initial clinical trial and pharmacokinetics of ThymitaqTM (AG337) by 10-day continuous infusion in patients with advanced solid tumors

โœ Scribed by Patrick J. Creaven; Lakshmi Pendyala; Neal J. Meropol; Neil J. Clendeninn; Ellen Y. Wu; Gregory M. Loewen; April Proefrock; Amanda Johnston; Mary Dixon


Publisher
Springer
Year
1997
Tongue
English
Weight
135 KB
Volume
41
Category
Article
ISSN
0344-5704

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Phase I clinical trial and pharmacokinet
โœ Charles L. Vogel; Elizabeth Gorowski; Enrique Davila; Mario Eisenberger; James K ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer US ๐ŸŒ English โš– 823 KB

ICRF-187 was given to 62 evaluable patients with advanced solid tumors in a Phase I clinical trial. Weekly infusions were given in dosages ranging from 0.85 g/m2 to 7.42 g/m2 for a total of four weeks with a two week rest period between courses. Dose-limiting hematological toxicity was seen in heavi