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A phase I pharmacokinetics study of 9-nitrocamptothecin in patients with advanced solid tumors

✍ Scribed by Zhao Yan; Zhongling Zhu; Kai Li; Peng Chen; Liuchun Wang; Chun Huang; Jinhuai Xue; Meijun Liu


Publisher
Springer
Year
2010
Tongue
English
Weight
209 KB
Volume
67
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND 9‐Nitrocamptothecin (9‐NC) is an orally available camptothecin analog with antineoplastic activity that results from the inhibition of DNA topoisomerase I. Previous studies have suggested that it has significant clinical efficacy. The primary toxicities of 9‐NC include ga