A phase II study of 9-nitrocamptothecin in patients with advanced pancreatic adenocarcinoma
β Scribed by Manousos M. Konstadoulakis; Pantelis T. Antonakis; Basil G. Tsibloulis; George P. Stathopoulos; Andreas P. Manouras; Despoina B. Mylonaki; Basil X. Golematis
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 72 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
To determine the efficacy of amonafide in patients with advanced, measurable pancreatic adenocarcinoma, 15 patients previously untreated with chemotherapy were entered on a phase II trial. The starting dose was 400 mg/m 2 administered daily over 1 hr for 5 consecutive days repeated every 3 weeks. Be
## Abstract ## BACKGROUND The authors conducted a 2βarm Phase II trial of 9βnitrocamptothecin (9βNC), an oral topoisomerase I inhibitor, to define response rates in patients with gastrointestinal (GI) leiomyosarcomas and other softβtissue sarcomas (STS). ## METHODS Patients were required to prov