𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors

✍ Scribed by David S. Hong; James L. Abbruzzese; Karla Bogaard; Yvonne Lassere; Masakazu Fukushima; Akira Mita; Keizo Kuwata; Paulo M. Hoff


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
176 KB
Volume
107
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


A phase I study of sequential administra
✍ Caio M. S. Rocha Lima; Carlo V. Catapano; Daniel Pacheco; Carol A. Sherman; Greg πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 114 KB πŸ‘ 1 views

## Abstract ## BACKGROUND Based on preclinical findings and on the clinical antitumor efficacy of sequential paclitaxel/topotecan and topotecan/etoposide, the authors sought to define the maximum tolerated doses (MTDs) and dose‐limiting toxicities (DLTs) associated with a sequential combination of

A multicenter Phase I safety study of in
✍ Robert A. Lustig; Thomas J. Vogl; David Fromm; Rosa Cuenca; R. Alex Hsi; Anil K. πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 87 KB πŸ‘ 1 views

## Abstract ## BACKGROUND Photodynamic therapy (PDT) currently is approved for the palliative treatment of malignancies of the aerodigestive tract using laser‐activated porfimer sodium. A new approach has been developed, based on intratumoral placement of a nonlaser light device that activates tal

Phase I and pharmacokinetic study of a s
✍ Ruey-Long Hong; Yun-Long Tseng πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 99 KB πŸ‘ 2 views

## BACKGROUND. Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study o

A Phase I–II study of sequential adminis
✍ Tony S. K. Mok; Herman Wong; Benny Zee; Kwok Hung Yu; Thomas W. T. Leung; Tak Wa πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 87 KB πŸ‘ 1 views

## Abstract ## BACKGROUND Topotecan (9‐dimethylaminomethyl‐10‐hydroxycampthothecin) is a new topoisomerase I inhibitor with promising efficacy in the treatment of patients with small cell lung carcinoma (SCLC). Combination with a topoisomerase II inhibitor may potentate the therapeutic effect of t