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Peptide deformylase inhibitors with non-peptide scaffold: Synthesis and structure–activity relationships

✍ Scribed by Seung Kyu Lee; Kwang Hyun Choi; Sang Jae Lee; Jong Sun Lee; Ji Yun Park; B. Moon Kim; Bong Jin Lee

Book ID: 104005129
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 576 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.11.056

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✦ Synopsis

Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors.

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