Peptide deformylase inhibitors with non-
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Seung Kyu Lee; Kwang Hyun Choi; Sang Jae Lee; Jong Sun Lee; Ji Yun Park; B. Moon
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Article
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2011
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Elsevier Science
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English
⚖ 576 KB
Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors.