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Peptide deformylase inhibitors with retro-amide scaffold: Synthesis and structure–activity relationships

✍ Scribed by Seung Kyu Lee; Kwang Hyun Choi; Sang Jae Lee; Se Won Suh; B. Moon Kim; Bong Jin Lee


Book ID
118426605
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
418 KB
Volume
20
Category
Article
ISSN
0960-894X

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Peptide deformylase inhibitors with non-
✍ Seung Kyu Lee; Kwang Hyun Choi; Sang Jae Lee; Jong Sun Lee; Ji Yun Park; B. Moon 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 576 KB

Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors.