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Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

โœ Scribed by Wei Shi; Haikun Ma; Yuejiao Duan; Kelly Aubart; Yuhong Fang; Rimma Zonis; Liping Yang; Wenhao Hu


Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
451 KB
Volume
21
Category
Article
ISSN
0960-894X

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The drug resistant bacteria pose a severe threat to human health. The increasing resistance of those pathogens to traditional antibacterial therapy renders the identification of new antibacterial agents with novel antibacterial mechanisms an urgent need. In this study, a series of (2S)-N-substituted