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Path analysis and sib-pair linkage

✍ Scribed by Gregory Carey; John A. Williamson

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 386 KB
Volume: 10
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370100203

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✦ Synopsis

When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coefficient is developed and a method for fitting a covariance matrix predicted by a specific ordering of loci to an observed covariance matrix is proposed. Q 1993 Wiley-Liss. Inc.

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