When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coeff
Model-free sib-pair linkage analysis: Combining full-sib and half-sib pairs
β Scribed by Daniel J. Schaid; Robert C. Elston; Lieu Tran; Alexander F. Wilson
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 278 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0741-0395
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For each marker locus and for every pair of sibs with data available in the 1983 workshop data, the proportion of genes identical by descent was estimated. The mean proportions were compared between concordant and discordant sib pairs, and the mean proportion for concordantly affected pairs was comp
Sib pairs drawn from the simulated common oligogenic disease families were selected for extreme quantitative trait scores and analyzed using interval mapping and multipoint methods. Linkage analyses of 112 selected sib pairs, in which one or more members had trait values exceeding the disease thresh
## Abstract Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105β122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared IBD (identityβbyβdecent) from affected sib pairs. Th