Papovavirus SV40: Similarity of tumor antigens in transformed virus-free hamster cells and in virus-infected monkey cells

✍ Scribed by Tsunehiro Kitahara; Joseph L. Melnick; Fred Rapp

• Publisher: John Wiley and Sons
• Year: 1966
• Tongue: French
• Weight: 453 KB
• Volume: 1
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910010304

✦ Synopsis

Sera from hamsters bearing tumors induced by papovavirus SV40 reacted with tumor antigen prepared either from cells transformed by, or from cells infected with, the homologous virus. Serum titers against both antigens were comparable. A high degree of correlation was obtained with the use of either complement-fixation or immunofluorescence to detect the antigen. The immunofluorescent intranuclear antigen present in cells transformed by SV40, and the early virus-induced intranuclear antigen found during the cytolytic cycle following infection of monkey cells by SV40, therefore appear to be similar, and they are either identical with or similar to the antigens detected by complement-fixation techniques. Synthesis of antibody against this antigen was detected only in hamsters bearing tumors induced by SV40 or by cells transformed by the virus. Hamsters immunized with S V40 usually reject cells transformed by the homologous virus; the few vaccinated animals which fail to reject such cells also fail to produce untibodies against tumor antigen although the tumor cells in such animals continue to synthesize the antigen.