𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Herpes simplex virus-induced amplification of SV40 sequences in transformed Chinese hamster embryo cells

✍ Scribed by Jörg R. Schlehofer; Lutz Gissmann; Bertfried Matz; Harald Zur Hausen

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
426 KB
Volume
32
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Infection with Herpes simplex viruses (HSV) induces amplification of SV40 sequences in SV40‐transformed Chinese hamster embryo cells (CO631). This is shown by in situ hybridization of the infected cells with cloned ^32^P‐labelled SV40 DNA. The HSV‐mediated synthesis of SV40 DNA is more pronounced than after treatment with chemical carcinogens. This initiator‐like effect of HSV may, in concert with the previously reported mutagenic activity of this virus (Schlehofer and zur Hausen, 1982), point to a possible mechanism of HSV infection in human genital cancer.

📜 SIMILAR VOLUMES

Inhibition of initiator-induced SV40 gen
Inhibition of initiator-induced SV40 gene amplification in SV40-transformed Chinese hamster cells by infection with a defective parvovirus
✍ Jörg R. Schlehofer; Regine Heilbronn; Brigitte Georg-Fries; Harald Zur Hausen 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 469 KB 👁 1 views

## Abstract Amplification of SV40 genes in SV40‐transformed Chinese hamster embryo cells (CO631) by chemical carcinogens as well as by herpes simplex virus infection can be inhibited by infection with the defective parvovirus, AAV‐5. This is shown by __in situ__ hybridization with SV40 DNA of AAV‐5