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Expression of fetal antigens and tumor-specific antigens in SV40-transformed cells. II. Tumor transplantation studies

✍ Scribed by Chou-Chik Ting; Dennis Rodrigues; Ronald B. Herberman

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
343 KB
Volume
12
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The effect of immunization with fetal antigens and tumor‐specific antigens on the transplantation of SVT2, a BALB/c mouse tumor induced by Simian virus 40 (SV40), has been studied. Hyperimmunization with 5,000 R X‐irradiated, syngeneic fetuses of 1–2 weeks' gestation or syngeneic spleen cells gave no protection to SVT2 cell challenge. In contrast, immunization with SV40 or SV40‐transformed cells gave a 100‐ to 1,000‐fold protection. These results gave additional evidence that fetal antigens are different from tumor‐specific transplantation antigen (TSTA).

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