✦ LIBER ✦

In vivo induction of tumor-specific immunity by glycolipid extracts of SV40-transformed cells

✍ Scribed by Sandra Ansel; Daniel Blangy

Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 482 KB
Volume: 34
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910340419

No coin nor oath required. For personal study only.

✦ Synopsis

Glycolipid extracts were prepared from various Syrian golden hamster cell lines, either SV40-transformed or spontaneously transformed. To detect possible SV40-TSTA activity of the glycolipid preparations. normal hamsten were inoculated with different glycolipid extracts and were subsequently challenged with an SV40 tumor-cell line. Significant immunoprotection against SV40 tumor challenge was induced with glycolipids obtained from SV40-transformed cell lines. This was expressed as complete tumor rejection or as a decrease in tumor growth rate, when compared to controls. No protective effects were induced with glycolipid extracts from spontaneously transformed cells. Results suggest that tumor-specifK glycolipids synthesized in cells transformed by SV40 virus could act as tumor transplantation antigens responsible for specific tumor rejection in syngeneic hosts.

📜 SIMILAR VOLUMES

Expression of fetal antigens and tumor-s

Expression of fetal antigens and tumor-specific antigens in SV40-transformed cells. II. Tumor transplantation studies

✍ Chou-Chik Ting; Dennis Rodrigues; Ronald B. Herberman 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 343 KB 👁 1 views

## Abstract The effect of immunization with fetal antigens and tumor‐specific antigens on the transplantation of SVT2, a BALB/c mouse tumor induced by Simian virus 40 (SV40), has been studied. Hyperimmunization with 5,000 R X‐irradiated, syngeneic fetuses of 1–2 weeks' gestation or syngeneic spleen

Study of the in vivo fixation of antibod

Study of the in vivo fixation of antibodies on tumors provoked in hamsters by injection of SV40-transformed cells (TSV5Cl2)

✍ E. Sobczak; Ch. de Vaux Saint Cyr 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 430 KB 👁 1 views

## Large particle fraction obtained by the technique of Sjogren and Motet (1969) can be treated at acid P H , to elute immunoglobulins from hamster tumors induced by injection of SV-40 transformed fibroblasts (TSV,CI,). The eluate contains IgGz 7S, as well as two fragments having molecular we

Kinetics of costimulatory molecule expre

Kinetics of costimulatory molecule expression by T cells and dendritic cells during the induction of tolerance versus immunity in vivo

✍ Kristin Hochweller; Stephen M. Anderton 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB 👁 1 views

## Abstract Steady‐state dendritic cells (DC) present peptide‐MHC complexes to T cells in a tolerogenic manner, presumably because of deficient costimulation. However, it is clear that the path to tolerance involves initial T cell activation, suggesting that the deficit may lie in late‐acting costi

Transplantable Marek's disease lymphomas

Transplantable Marek's disease lymphomas. III. Induction of MHC-restricted tumor immunity by lymphoblastoid cells in F1 hosts

✍ Nancy L. Difronzo; Louis W. Schierman 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 336 KB 👁 1 views

## MHC-RESTRICTED TUMOR IMMUNITY BY LYMPHOBLASTOID CELLS IN F, chickens, which were a cross between birds of the related inbred lines G-61 and G-62, were immunized with in vitro cultured virus-non-producer lymphoblastoid cells that were either syngeneic or allogeneic with the challenge tumor cells

Suppression of the transformed phenotype

Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone

✍ Martina Blumenthal; Adel Kardosh; Louis Dubeau; Zea Borok; Axel H. Schönthal 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 263 KB

## Abstract Epidemiological evidence suggests that elevated levels of the pregnancy hormone progesterone might play a role in the reduced risk of women to develop ovarian cancer. In vitro studies have supported this hypothesis by demonstrating negative effects of this hormone on the growth and prol

In vivo activation of melanoma-specific

In vivo activation of melanoma-specific CD8+ T cells by endogenous tumor antigen and peptide vaccines. A comparison to virus-specific T cells

✍ Daniel E. Speiser; Danielle Liénard; Mikaël J. Pittet; Pascal Batard; Donata Rim 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB 👁 2 views