Evidence for virus-specific transplantation antigen in cells of lymphoid neoplasms induced by papovavirus sv40
✍ Scribed by S. S. Tevethia
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- French
- Weight
- 430 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Hamster lymphocyte leukemia and lymphosarcoma induced in vivo by papova‐virus SV40 were tested for the presence of SV40‐specific transplantation antigen. The cells derived from lymphocytic leukemia (GD‐248) blocked primary SV40 oncogenesis in vivo and also immunized adult hamsters against the transplantation of SV40 tumor cells which have been shown to carry SV40‐specific transplantation antigen. Lymphosarcoma cells (GD‐36), although immunosensitive, were not effective in blocking SV40 oncogenesis. GD‐36 cells were also less immunogenic than GD‐248 cells. These results indicate that the appearance of lymphoid cell tumors in adult hamsters by SV40 is not due to the absence of SV40‐specific transplantation antigen in these tumors.