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p53 codon 249ser mutations in hepatocellular carcinoma patients with low aflatoxin exposure

✍ Scribed by Patel, Pragna; Stephenson, Janet; Scheuer, PeterJ.; Francis, GillianE.

Book ID
121967183
Publisher
The Lancet
Year
1992
Tongue
English
Weight
167 KB
Volume
339
Category
Article
ISSN
0140-6736

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## Abstract A mutation in the tumor suppressor __p53__ gene resulting in an Arg→Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure. To determine the significance of this mutation in an in vivo exp