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P53 codon 249 mutation and other risk factors among Nigerians with hepatocellular carcinoma

✍ Scribed by R. Igetei; J. A. Otegbayo; O. A. Lesi; C. I. Anumudu; D. A. Ndububa

Book ID
107665355
Publisher
Springer-Verlag
Year
2010
Tongue
French
Weight
122 KB
Volume
2
Category
Article
ISSN
1965-0817

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## Abstract In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the __p__53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and ge